Eosinophilic Granuloma Complex (EGC)

Eosinophilic Granuloma Complex (EGC)

Species: Cat

Breeds Affected: All breeds

A group of skin lesions believed to be due to allergic hypersensitivity. EGC includes rodent ulcers (upper lip ulcers), eosinophilic plaques, and linear granulomas. Lesions commonly occur on the lips, in the mouth, or on the thighs/abdomen. The condition often recurs without addressing the underlying allergy (eg, fleas or food).

• Raised
• reddened
• often moist lesions on the skin or ulcerative sores. A classic form is the “rodent ulcer” on the upper lip – a swollen
• red ulcer along the lip margin. Other lesions include itchy
• oozing plaques on the belly or hind legs
• or linear firm swellings on the thighs. Lesions can be painful or itchy.

Identify and remove the underlying cause if possible (strict flea control and hypoallergenic diet trials). Corticosteroids are the first-line treatment to reduce lesions and inflammation. Long-acting steroid injections or oral prednisolone may be used for weeks to months to prevent recurrence. In refractory cases, an immunosuppressant such as cyclosporine may be used. If a lesion is infected, antibiotics are indicated.

Prednisolone or dexamethasone to reduce inflammation and shrink lesions; cyclosporine (Atopica®) for chronic cases; antibiotics (eg, amoxicillin-clavulanate) if secondary infection occurs; antihistamines or essential fatty acids as adjuncts.