Addison’s Disease (Hypoadrenocorticism)

Addison’s Disease (Hypoadrenocorticism)

Species: Dog

Breeds Affected: All breeds can be affected; however, certain breeds (e.g. Standard Poodles, Bearded Collies, Portuguese Water Dogs, Nova Scotia Duck Tolling Retrievers, Leonbergers, Great Danes, Labrador Retrievers) have a higher risk

Addison’s disease is an endocrine disorder in which the adrenal glands fail to produce sufficient cortisol and aldosterone. It is often caused by immune-mediated destruction of the adrenal cortex. The resulting hormone deficiency disrupts salt balance and stress responses, leading to life-threatening issues if untreated.

• Dogs may experience lethargy
• vomiting
• diarrhea
• weight loss
• increased thirst and urination
• and occasional shaking. In an acute crisis
• dogs can collapse with shock
• severe vomiting/diarrhea
• and weakness.

Acute crises are managed with intensive care (IV fluids, electrolytes, dextrose, and corticosteroids). Long-term management involves hormone replacement therapy.

Mineralocorticoid replacement (e.g. desoxycorticosterone pivalate) and glucocorticoids (e.g. prednisone) are used for lifelong management.

• Columbus Veterinary Reviews , Columbus
• The Veterinary Relief Company , Columbus
• James Herriot Memorial Veterinary Hospital , Columbus
• German Village Veterinary Hospital , Columbus
• East Columbus Veterinary Hospital , Columbus