Addison’s Disease (Hypoadrenocorticism)
Detailed information about Addison’s Disease (Hypoadrenocorticism)
Addison’s Disease (Hypoadrenocorticism)
Species: Dog
Breeds Affected: All breeds can be affected; however, certain breeds (e.g. Standard Poodles, Bearded Collies, Portuguese Water Dogs, Nova Scotia Duck Tolling Retrievers, Leonbergers, Great Danes, Labrador Retrievers) have a higher risk
Overview
Addison’s disease is an endocrine disorder in which the adrenal glands fail to produce sufficient cortisol and aldosterone. It is often caused by immune-mediated destruction of the adrenal cortex. The resulting hormone deficiency disrupts salt balance and stress responses, leading to life-threatening issues if untreated.
Symptoms
- Dogs may experience lethargy
- vomiting
- diarrhea
- weight loss
- increased thirst and urination
- and occasional shaking. In an acute crisis
- dogs can collapse with shock
- severe vomiting/diarrhea
- and weakness.
Treatments
Acute crises are managed with intensive care (IV fluids, electrolytes, dextrose, and corticosteroids). Long-term management involves hormone replacement therapy.
Medications
Mineralocorticoid replacement (e.g. desoxycorticosterone pivalate) and glucocorticoids (e.g. prednisone) are used for lifelong management.
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