Cushing’s Disease (Hyperadrenocorticism)

Cushing’s Disease (Hyperadrenocorticism)

Species: Dog

Breeds Affected: Any dog can develop Cushing’s; however, small breeds (e.g. Miniature Poodles, Dachshunds, Yorkshire Terriers, Boston Terriers, Boxers) and certain larger breeds (e.g. German Shepherds) are predisposed

Cushing’s disease is caused by chronic overproduction of cortisol. Approximately 85% of cases are due to a benign pituitary tumor (pituitary-dependent Cushing’s) or an adrenal tumor; iatrogenic Cushing’s can also occur with long-term steroid use.

• Dogs typically exhibit increased appetite
• increased thirst and urination
• lethargy
• a pot-bellied appearance
• panting
• thin skin with hair loss
• and recurrent infections.

For pituitary-dependent cases, oral medications (e.g. trilostane) are used; for adrenal tumors, surgical removal may be curative.

Trilostane is FDA-approved and is the primary drug used. Alternatives include mitotane, ketoconazole, or selegiline, with additional supportive care as needed.

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